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1

Mouse complement components C4 and Slp act synergistically in a homologous hemolytic C4 assay

Frank J. M. Beurskens, Mario Tosi, Toshihiko Shiroisho, Diane M. Robins, Michael C. Carroll, Hans van Dijk

Journal:

European Journal of Immunology

Year:

2000

Language:

english

File:

PDF, 96 KB

english, 2000

2

Targeting interleukin-15 in patients with rheumatoid arthritis: A proof-of-concept study

Bo Baslund, Niels Tvede, Bente Danneskiold-Samsoe, Per Larsson, Gabriel Panayi, Joergen Petersen, Lars J. Petersen, Frank J. M. Beurskens, Janine Schuurman, Jan G. J. van de Winkel, Paul W. H. I. Parr

Journal:

Arthritis & Rheumatism

Year:

2005

Language:

english

File:

PDF, 94 KB

english, 2005

3

Penetration of antibody-opsonized cells by the membrane attack complex of complement promotes Ca2+ influx and induces streamers

Paul V. Beum, Margaret A. Lindorfer, Elizabeth M. Peek, P. Todd Stukenberg, Michel de Weers, Frank J. Beurskens, Paul W. H. I. Parren, Jan G. J. van de Winkel, Ronald P. Taylor

Journal:

European Journal of Immunology

Year:

2011

Language:

english

File:

PDF, 378 KB

english, 2011

4

Does complement component C4A protect from autoimmune diseases

Frank J.M. Beurskens, Hans van Dijk, Diana M. Robins

Journal:

Immunology Today

Year:

1997

File:

PDF, 63 KB

1997

5

Fc receptor but not complement binding is important in antibody protection against HIV

Hunter, Meredith, Havenith, Carin E. G., Beurskens, Frank J., Bakker, Joost M., Lanigan, Caroline M. S., Landucci, Gary, Forthal, Donald N., Parren, Paul W. H. I., Hessell, Ann J., Hangartner, Lars

Journal:

Year:

2007

Language:

english

File:

PDF, 396 KB

english, 2007

6

Complement-dependent lysis of mAb-opsonized B cells can increase resistance of naïve B cells to subsequent attack by mAb and complement

Ronald P. Taylor, Paul V. Beum, Margaret A. Lindorfer, Andrew W. Pawluzckowycz, Frank J. Beurskens, Jan G.J. van de Winkel, Paul W.H.I. Parren

Journal:

Molecular Immunology

Year:

2010

Language:

english

File:

PDF, 71 KB

english, 2010

7

Complement activation by (auto-) antibodies

Nina A. Daha, Nirmal K. Banda, Anja Roos, Frank J. Beurskens, Joost M. Bakker, Mohamed R. Daha, Leendert A. Trouw

Journal:

Molecular Immunology

Year:

2011

Language:

english

File:

PDF, 303 KB

english, 2011

8

A role for lipid rafts in C1q-triggered O2− generation by human neutrophils

Iyore Otabor, Shivraj Tyagi, Frank J.M Beurskens, Ionita Ghiran, Pascale Schwab, Anne Nicholson-Weller, Lloyd B Klickstein

Journal:

Molecular Immunology

Year:

2004

Language:

english

File:

PDF, 275 KB

english, 2004

9

Spinning disk confocal fluorescent microscopy (SDCFM) analyses of complement activation promoted by anti-CD20 mAbs rituximab and ofatumumab (HuMax-CD20)

Ronald P. Taylor, Paul V. Beum, Andrew W. Pawluczkowycz, Frank Beurskens, Jan Van de Winkel, Paul Parren

Journal:

Molecular Immunology

Year:

2007

Language:

english

File:

PDF, 66 KB

english, 2007

10

Sex-limited protein and its role in the precipitation-inhibition and solubilization of immune complexes

Ilse van Binsbergen, Marsha Korthout, Frank Beurskens, Hans van Dijk

Journal:

Molecular Immunology

Year:

1998

File:

PDF, 366 KB

1998

11

Sex-limited protein: in-vitro and in-vivo functions

Frank Beurskens, Piet Aerts, Diane M. Robins, Hans van Dijk

Journal:

Molecular Immunology

Year:

1998

File:

PDF, 325 KB

1998

12

Type I CD20 antibodies take over the B-cell receptor for complement-dependent cytotoxicity (CDC) of malignant B cells

Patrick J. Engelberts, Marleen Voorhorst, Janine Schuurman, Tom van Meerten, Joost M. Bakker, Tom Vink, Wendy J.M. Mackus, Jan G.J. van de Winkel, Paul W.H.I. Parren, Frank J. Beurskens

Journal:

Year:

2012

Language:

english

File:

PDF, 70 KB

english, 2012

13

A quantitative flow cytometric assay for determining binding characteristics of chimeric, humanized and human antibodies in whole blood: Proof of principle with rituximab and ofatumumab

Engelberts, Patrick J., Badoil, Carole, Beurskens, Frank J., Boulay-Moine, Danièle, Grivel, Karine, Parren, Paul W.H.I., Moulard, Maxime

Journal:

Journal of Immunological Methods

Year:

2013

Language:

english

File:

PDF, 664 KB

english, 2013

14

The Economics of Dot.coms and E-Commerce in the Agrifood Sector

Frank Beurskens

Journal:

Review of Agricultural Economics

Year:

2003

Language:

english

File:

PDF, 664 KB

english, 2003

15

Complement in therapy and disease

Melis, Joost P.M., Strumane, Kristin, Ruuls, Sigrid R., Beurskens, Frank J., Schuurman, Janine, Parren, Paul W.H.I.

Journal:

Molecular Immunology

Year:

2015

Language:

english

File:

PDF, 2.84 MB

english, 2015

16

The Economics of Dot.coms and E-commerce in the Agrifood Sector

Beurskens, Frank

Journal:

Review of Agricultural Economics

Year:

2003

Language:

english

File:

PDF, 100 KB

english, 2003

17

C1q, antibodies and anti-C1q autoantibodies

Beurskens, Frank J., van Schaarenburg, Rosanne A., Trouw, Leendert A.

Journal:

Molecular Immunology

Year:

2015

Language:

english

File:

PDF, 1.42 MB

english, 2015

18

Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

van den Bremer, Ewald TJ, Beurskens, Frank J, Voorhorst, Marleen, Engelberts, Patrick J, de Jong, Rob N, van der Boom, Burt G, Cook, Erika M, Lindorfer, Margaret A, Taylor, Ronald P, van Berkel, Patri

Journal:

Year:

2015

Language:

english

File:

PDF, 887 KB

english, 2015

19

Real-time analysis of the detailed sequence of cellular events in mAb-mediated complement-dependent cytotoxicity of B-cell lines and of chronic lymphocytic leukemia B-cells

Lindorfer, Margaret A., Cook, Erika M., Tupitza, Jillian C., Zent, Clive S., Burack, Richard, de Jong, Rob N., Beurskens, Frank J., Schuurman, Janine, Parren, Paul W.H.I., Taylor, Ronald P.

Journal:

Molecular Immunology

Year:

2016

Language:

english

File:

PDF, 4.22 MB

english, 2016

20

Impact of IgG oligomerization state on the potency of complement-dependent cytotoxicity

Beurskens, Frank J., de Jong, Rob N., Wang, Guanbo, Voorhorst, Marleen, van den Bremer, Ewald T.J., Labrijn, Aran F., Schuurman, Janine, Heck, Albert J.R., Parren, Paul W.H.I.

Journal:

Year:

2016

Language:

english

File:

PDF, 68 KB

english, 2016

21

Antibodies that efficiently form hexamers upon antigen binding can induce complement-dependent cytotoxicity under complement-limiting conditions

Taylor, Ronald P., Lindorfer, Margaret A., Cook, Erika M., Beurskens, Frank J., van der Horst, Hilma, Oostindie, Simone, Schuurman, Janine, Zent, Clive, Burack, Richard, Parren, Paul W.H.I.

Journal:

Year:

2016

Language:

english

File:

PDF, 54 KB

english, 2016

22

NIH Public Access

Diebolder, Christoph A, Beurskens, Frank J, Jong, Rob N De, Koning, Roman I, Strumane, Kristin, Lindorfer, Margaret A, Voorhorst, Marleen, Ugurlar, Deniz, Heck, Albert J R, Winkel, Jan G J Van De, Wil

Year:

2014

Language:

english

File:

PDF, 1.15 MB

english, 2014

23

Monoclonal Antibodies against Epidermal Growth Factor Receptor Acquire an Ability To Kill Tumor Cells through Complement Activation by Mutations That Selectively Facilitate the Hexamerization of IgG on Opsonized Cells

Tammen, Annalina, Derer, Stefanie, Schwanbeck, Ralf, Rösner, Thies, Kretschmer, Anna, Beurskens, Frank J., Schuurman, Janine, Parren, Paul W. H. I., Valerius, Thomas

Journal:

The Journal of Immunology

Year:

2017

Language:

english

File:

PDF, 1.48 MB

english, 2017

24

Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9

Taylor, Ronald P., Lindorfer, Margaret A., Cook, Erika M., Beurskens, Frank J., Schuurman, Janine, Parren, Paul W.H.I., Zent, Clive S., VanDerMeid, Karl R., Burack, Richard, Mizuno, Masashi, Paul Morg

Journal:

Clinical Immunology

Year:

2017

Language:

english

File:

PDF, 534 KB

english, 2017

25

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

Losen, Mario, Labrijn, Aran F., van Kranen-Mastenbroek, Vivianne H., Janmaat, Maarten L., Haanstra, Krista G., Beurskens, Frank J., Vink, Tom, Jonker, Margreet, ‘t Hart, Bert A., Mané-Damas, Marina, M

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.97 MB

english, 2017

26

Impact of carbamylation on IgG mediated complement activation

Lubbers, Rosalie, Oostindie, Simone C., Parren, Paul W., Beurskens, Frank J., Trouw, Leendert A.

Journal:

Molecular Immunology

Year:

2017

Language:

english

File:

PDF, 46 KB

english, 2017

27

Ins Feld und zurück - Praktische Probleme qualitativer Forschung in der Sozialgeographie || Rauchzeichen und Zwischentöne. Unterwegs mit Zigaretten und Vignetten

Meyer, Frank, Miggelbrink, Judith, Beurskens, Kristine

Year:

2018

Language:

german

File:

PDF, 184 KB

german, 2018

28

Hexamerization-enhanced CD37 and CD20 antibodies synergize in CDC to kill patient-derived CLL cells with unprecedented potency

Taylor, Ronald, Lindorfer, Margaret, Oostindie, Simone, Cook, Erika, Zent, Clive, Burack, Richard, Beurskens, Frank, Schuurman, Janine, Breij, Esther, Parren, Paul

Journal:

Molecular Immunology

Year:

2018

Language:

english

File:

PDF, 46 KB

english, 2018

29

Immune effector functions of human IgG2 antibodies against EGFR

Rösner, Thies, Kahle, Steffen, Montenegro, Francesca, Matlung, Hanke L, Jansen, J. H. Marco, Evers, Mitchell, Beurskens, Frank, Leusen, Jeanette H.W., van den Berg, Timo K, Valerius, Thomas

Journal:

Molecular Cancer Therapeutics

Year:

2018

Language:

english

File:

PDF, 3.24 MB

english, 2018

30

C1q potentiates DR5 agonist activity by a mixture of two DR5-specific HexaBody® molecules

Beurskens, Frank, Overdijk, Marije, Strumane, Kristin, Buijsse, Antonio Ortiz, Vermot-Desroches, Claudine, Kroes, Thessa, de Jong, Bart, Hoevenaars, Naomi, de Jong, Rob, Lingnau, Andreas, Parren, Paul

Journal:

Molecular Immunology

Year:

2018

Language:

english

File:

PDF, 56 KB

english, 2018

31

Potentiation of efficacy of a candidate immunotherapeutic antibody to Neisseria gonorrhoeae by enhancing IgG Fc hexamer formation

Gulati, Sunita, Beurskens, Frank J., de Kreuk, Bart-Jan, Roza, Marcel, Zheng, Bo, Taylor, Ronald P., Botto, Marina, Schuurman, Janine, Rice, Peter A., Ram, Sanjay

Journal:

Molecular Immunology

Year:

2018

Language:

english

File:

PDF, 54 KB

english, 2018

32

Unraveling the macromolecular pathways of IgG oligomerization and complement activation on antigenic surfaces

Strasser, Juergen, de Jong, Rob N., Beurskens, Frank J., Wang, Guanbo, Heck, Albert J.R., Schuurman, Janine, Parren, Paul W.H.I., Hinterdorfer, Peter, Preiner, Johannes

Journal:

Year:

2019

Language:

english

File:

PDF, 1.31 MB

english, 2019

33

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

Gulati, Sunita, Beurskens, Frank J., de Kreuk, Bart-Jan, Roza, Marcel, Zheng, Bo, DeOliveira, Rosane B., Shaughnessy, Jutamas, Nowak, Nancy A., Taylor, Ronald P., Botto, Marina, He, Xianbao, Ingalls,

Journal:

Year:

2019

Language:

english

File:

PDF, 5.16 MB

english, 2019

34

Weak Fragment Crystallizable (Fc) Domain Interactions Drive the Dynamic Assembly of IgG Oligomers upon Antigen Recognition

Strasser, Jürgen, de Jong, Rob N., Beurskens, Frank J., Schuurman, Janine, Parren, Paul W. H. I., Hinterdorfer, Peter, Preiner, Johannes

Journal:

Year:

2019

Language:

english

File:

PDF, 910 KB

english, 2019

35

Weak Fragment Crystallizable (Fc) Domain Interactions Drive the Dynamic Assembly of IgG Oligomers upon Antigen Recognition

Strasser, Jürgen, de Jong, Rob N., Beurskens, Frank J., Schuurman, Janine, Parren, Paul W. H. I., Hinterdorfer, Peter, Preiner, Johannes

Journal:

Year:

2019

File:

PDF, 910 KB

2019

36

Bypassing Phase Variation of Lipooligosaccharide (LOS): Using Heptose 1 Glycan Mutants To Establish Widespread Efficacy of Gonococcal Anti-LOS Monoclonal Antibody 2C7

Chakraborti, Srinjoy, Gulati, Sunita, Zheng, Bo, Beurskens, Frank J., Schuurman, Janine, Rice, Peter A., Ram, Sanjay, Raffatellu, Manuela

Journal:

Infection and Immunity

Year:

2019

File:

PDF, 1.28 MB

2019

37

A closer look at the paralyzed face; a narrative review of the neurobiological basis for functional and aesthetic appreciation between patients with a left and a right peripheral facial palsy

Tieman, Thomas E., Chaiet, Scott R., Luijmes, Robin, Sanches, Elijah, de Jongh, Frank W., Ingels, Koen J.A.O., Beurskens, Carien H.G., Monstrey, Stan J., Siemann, Ietske, Erasmus, Corrie E., Verhage-D

Journal:

Journal of Plastic, Reconstructive & Aesthetic Surgery

Year:

2020

File:

PDF, 1.03 MB

2020

38

Dual epitope targeting and enhanced hexamerization by DR5 antibodies as a novel approach to induce potent anti-tumor activity through DR5 agonism

Overdijk, Marije B, Strumane, Kristin, Beurskens, Frank J., Ortiz Buijsse, Antonio, Vermot-Desroches, Claudine, Vuillermoz, Boris S, Kroes, Thessa, Jong, Bart de, Hoevenaars, Naomi, Hibbert, Richard G

Journal:

Molecular Cancer Therapeutics

Year:

2020

File:

PDF, 12.90 MB

2020